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Cisternal papaverine reverses vasospasm induced in animal models

Ogata et al. (1973) monkey

Kuwayama et al (1972) canine

Voller et al. (1988) rabbit

Kazuhiko et al., 1998: CR papaverine pellets applied to vessels reduced the severity/incidence of experimentally induced vasospasm in dogs.

Dalbasti et al., JNS July, 2001: 117 patients

73 control, 44 PapaCR group

PapaCR pellets placed in cisterns over arterial segments at the time of aneurysm surgery

Clinical vasospasm: 34/73 control vs. 1/44 PapaCR group

GOS at 1 month: 4.93 (0.05) PapaCR vs. 3.84 (1.63) control.