Go Back Brain/18. More than one of above/Normal, Technique, Anomaly/18.1 - Tuberous Sclerosis5/ Go to Index

Most commonly sporadic mutation

May also be autosomal dominant

Classic Triad: Seizures, mental retardation, and adenoma sebaceum (all three seen in only 50% of patients)

CNS manifestations

Subependymal nodules (75% Ca++)

Cortical and subcorical tubers (50% Ca++)

Subependymal Giant Cell Tumors

Ventriculomegaly.

Subependymal Giant Cell Astrocytoma.

Renal Angiomyolipomas. Lymphangioleiomyomatosis.