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Tuberous Sclerosis has hamartomas in many organs. It is manifested in the CNS by calcified subependymal nodules, subependymal giant cell astrocytomas, cortical hamartomas with balloon cells, and linear white matter tracts from neuronal migration and degenerative cystic lesions.

12% of tubers will enhance. 50% of cases inherited, autosomal dominant. SGCA in 15% of cases require yearly exams.